Chromium chloride with amla and shilajit8/14/2023 Good dietary sources of chromium include brewer's yeast, liver, potatoes with skin, beef, fresh vegetables, and cheese. The organic form of chromium exists in a dinicotino-glutathionine complex in natural foods, which is better absorbed than the inorganic form. 1 Industrially, it is obtained from chrome ore, among other sources. SourceĬhromium (Cr) is abundant in the earth's crust and is found in concentrations ranging from 100 to 300 ppm. However, at higher dosages, such as those used in trials evaluating the efficacy of chromium in glycemic control, concern exists for potential genotoxic effects. No risk of genotoxicity at appropriate dosages over the short-term exists for chromium as a dietary supplement. Ingestion or exposure to certain forms of chromium may cause or contribute to GI irritation and ulcers, dermatitis, hemorrhage, circulatory shock, and renal tubule damage. Limited animal experimentation showed skeletal and neurological defects in the offspring of mice fed chromium picolinate. Information regarding safety and efficacy in pregnancy and lactation is lacking. Renal failure may be considered a relative contraindication. The potential for genotoxic effects exists at higher dosages. Daily dosages used in clinical trials for periods of up to 9 months range as follows: brewer's yeast up to 400 mcg/day chromium chloride 50 to 600 mcg/day chromium nicotinate 200 to 800 mcg/day chromium picolinate 60 to 1,000 mcg/day. The currently accepted value for chromium dietary intake is 25 mcg/day for women and 35 mcg/day for men. The role of supplemental chromium remains controversial. Clinical Overview UseĬhromium supplementation has been studied for a variety of indications, especially diabetes and weight loss, but clinical studies have shown inconsistent results. Further, it can be inferred that PPC 400 mcg has significant synergistic activity.Common Name(s): Chromium chloride, Chromium nicotinate, Chromium picolinate Conclusion: PPC 400 mcg showed significant improvement in endothelial function, lipid profile and biomarkers of oxidative stress in type 2 diabetics, followed by the combination of Phyllanthus emblica and Shilajit extracts, chromium picolinate, chromium polynicotinate, chromium dinicocysteinate and chromium chloride. Further, PPC 400 mcg produced significant improvement of biomarkers of oxidative stress and lipid profile compared to other groups. Results: Total 96 subjects completed the study. Laboratory safety parameters were measured at baseline and post treatment. Efficacy parameters were change in endothelial function(>6% change in reflection index(RI), biomarkers of oxidative stress and lipid profile after 12weeks treatment. In part II, 96 eligible subjects were randomized to chromium chloride 400mcg, Phyllanthus emblica 6mg and Shilajit 6mg, chromium picolinate 400mcg, chromium polynicotinate 400mcg and chromium dinicocysteinate 400mcg and compared to PPC 400mcg. In part I, PPC 400mcg produced significant improvement in endothelial function compared to PPC 200mcg and placebo. Methodology: Study was done in two parts. Present study was planned to evaluate effect of proprietary chromium complex(PPC) and its individual components on endothelial dysfunction and lipid profile in type 2diabetics. Chromium Supplementation enhances endothelial relaxation and may improve endothelial dysfunction. EFFECT OF PROPRIETARY CHROMIUM COMPLEX AND ITS INDIVIDUAL COMPONENTS VERSUS CHROMIUM PICOLINATE, CHROMIUM POLYNICOTINATE AND CHROMIUM DINICOCYSTEINATE ON ENDOTHELIAL FUNCTION, BIOMARKERS AND LIPID PROFILE IN TYPE 2 DIABETICS – A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY Abstractīackground: Hyperglycemia may induce endothelial dysfunction.
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |